Robust ACE2 protein expression localizes to the motile cilia of the respiratory tract epithelia and is not increased by ACE inhibitors or angiotensin receptor blockers.
Identifieur interne : 000301 ( Main/Exploration ); précédent : 000300; suivant : 000302Robust ACE2 protein expression localizes to the motile cilia of the respiratory tract epithelia and is not increased by ACE inhibitors or angiotensin receptor blockers.
Auteurs : Ivan T. Lee [États-Unis] ; Tsuguhisa Nakayama [États-Unis] ; Chien-Ting Wu [États-Unis] ; Yury Goltsev [États-Unis] ; Sizun Jiang [États-Unis] ; Phillip A. Gall [États-Unis] ; Chun-Kang Liao [Taïwan] ; Liang-Chun Shih [Taïwan] ; Christian M. Schürch [États-Unis] ; David R. Mcilwain [États-Unis] ; Pauline Chu [États-Unis] ; Nicole A. Borchard [États-Unis] ; David Zarabanda [États-Unis] ; Sachi S. Dholakia [États-Unis] ; Angela Yang [États-Unis] ; Dayoung Kim [États-Unis] ; Tomoharu Kanie [États-Unis] ; Chia-Der Lin [Taïwan] ; Ming-Hsui Tsai [Taïwan] ; Katie M. Phillips [États-Unis] ; Raymond Kim [États-Unis] ; Jonathan B. Overdevest [États-Unis] ; Matthew A. Tyler [États-Unis] ; Carol H. Yan [États-Unis] ; Chih-Feng Lin [Taïwan] ; Yi-Tsen Lin [Taïwan] ; Da-Tian Bau [Taïwan] ; Gregory J. Tsay [Taïwan] ; Zara M. Patel [États-Unis] ; Yung-An Tsou [Taïwan] ; Chih-Jaan Tai [Taïwan] ; Te-Huei Yeh [Taïwan] ; Peter H. Hwang [États-Unis] ; Garry P. Nolan [États-Unis] ; Jayakar V. Nayak [États-Unis] ; Peter K. Jackson [États-Unis]Source :
- medRxiv : the preprint server for health sciences ; 2020.
Abstract
We investigated the expression and subcellular localization of the SARS-CoV-2 receptor, angiotensin-converting enzyme 2 (ACE2), within the upper (nasal) and lower (pulmonary) respiratory tracts of healthy human donors. We detected ACE2 protein expression within the cilia organelle of ciliated airway epithelial cells, which likely represents the initial or early subcellular site of SARS-CoV-2 viral entry during respiratory transmission. We further determined whether ACE2 expression in the cilia of upper respiratory cells was influenced by patient demographics, clinical characteristics, co-morbidities, or medication use, and found no evidence that the use of angiotensin-converting enzyme inhibitors (ACEI) or angiotensin II receptor blockers (ARBs) increases ACE2 protein expression.
DOI: 10.1101/2020.05.08.20092866
PubMed: 32511516
PubMed Central: PMC7273284
Affiliations:
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Lee</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, California 94305</wicri:regionArea><wicri:noRegion>California 94305</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation><nlm:affiliation>These authors contributed equally: Ivan T. Lee, Tsuguhisa Nakayama, Chien-Ting Wu, Yury Goltsev.</nlm:affiliation><wicri:noCountry code="subField">Yury Goltsev</wicri:noCountry></affiliation></author><author><name sortKey="Nakayama, Tsuguhisa" sort="Nakayama, Tsuguhisa" uniqKey="Nakayama T" first="Tsuguhisa" last="Nakayama">Tsuguhisa Nakayama</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation><nlm:affiliation>These authors contributed equally: Ivan T. Lee, Tsuguhisa Nakayama, Chien-Ting Wu, Yury Goltsev.</nlm:affiliation><wicri:noCountry code="subField">Yury Goltsev</wicri:noCountry></affiliation></author><author><name sortKey="Wu, Chien Ting" sort="Wu, Chien Ting" uniqKey="Wu C" first="Chien-Ting" last="Wu">Chien-Ting Wu</name><affiliation wicri:level="2"><nlm:affiliation>Baxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Baxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation><nlm:affiliation>These authors contributed equally: Ivan T. Lee, Tsuguhisa Nakayama, Chien-Ting Wu, Yury Goltsev.</nlm:affiliation><wicri:noCountry code="subField">Yury Goltsev</wicri:noCountry></affiliation></author><author><name sortKey="Goltsev, Yury" sort="Goltsev, Yury" uniqKey="Goltsev Y" first="Yury" last="Goltsev">Yury Goltsev</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, California 94305</wicri:regionArea><wicri:noRegion>California 94305</wicri:noRegion></affiliation><affiliation><nlm:affiliation>These authors contributed equally: Ivan T. Lee, Tsuguhisa Nakayama, Chien-Ting Wu, Yury Goltsev.</nlm:affiliation><wicri:noCountry code="subField">Yury Goltsev</wicri:noCountry></affiliation></author><author><name sortKey="Jiang, Sizun" sort="Jiang, Sizun" uniqKey="Jiang S" first="Sizun" last="Jiang">Sizun Jiang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, California 94305</wicri:regionArea><wicri:noRegion>California 94305</wicri:noRegion></affiliation></author><author><name sortKey="Gall, Phillip A" sort="Gall, Phillip A" uniqKey="Gall P" first="Phillip A" last="Gall">Phillip A. Gall</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Liao, Chun Kang" sort="Liao, Chun Kang" uniqKey="Liao C" first="Chun-Kang" last="Liao">Chun-Kang Liao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Otolaryngology, National Taiwan University Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Shih, Liang Chun" sort="Shih, Liang Chun" uniqKey="Shih L" first="Liang-Chun" last="Shih">Liang-Chun Shih</name><affiliation wicri:level="1"><nlm:affiliation>Department of Otorhinolaryngology, China Medical University Hospital, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Otorhinolaryngology, China Medical University Hospital, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Graduate Institute of Biomedical Sciences, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Terry Fox Cancer Research Laboratory, Translational Medicine Center, China Medical University Hospital, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Terry Fox Cancer Research Laboratory, Translational Medicine Center, China Medical University Hospital, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author><author><name sortKey="Schurch, Christian M" sort="Schurch, Christian M" uniqKey="Schurch C" first="Christian M" last="Schürch">Christian M. Schürch</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, California 94305</wicri:regionArea><wicri:noRegion>California 94305</wicri:noRegion></affiliation></author><author><name sortKey="Mcilwain, David R" sort="Mcilwain, David R" uniqKey="Mcilwain D" first="David R" last="Mcilwain">David R. Mcilwain</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, California 94305</wicri:regionArea><wicri:noRegion>California 94305</wicri:noRegion></affiliation></author><author><name sortKey="Chu, Pauline" sort="Chu, Pauline" uniqKey="Chu P" first="Pauline" last="Chu">Pauline Chu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, California 94305</wicri:regionArea><wicri:noRegion>California 94305</wicri:noRegion></affiliation></author><author><name sortKey="Borchard, Nicole A" sort="Borchard, Nicole A" uniqKey="Borchard N" first="Nicole A" last="Borchard">Nicole A. Borchard</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Zarabanda, David" sort="Zarabanda, David" uniqKey="Zarabanda D" first="David" last="Zarabanda">David Zarabanda</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Dholakia, Sachi S" sort="Dholakia, Sachi S" uniqKey="Dholakia S" first="Sachi S" last="Dholakia">Sachi S. Dholakia</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Yang, Angela" sort="Yang, Angela" uniqKey="Yang A" first="Angela" last="Yang">Angela Yang</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Kim, Dayoung" sort="Kim, Dayoung" uniqKey="Kim D" first="Dayoung" last="Kim">Dayoung Kim</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Kanie, Tomoharu" sort="Kanie, Tomoharu" uniqKey="Kanie T" first="Tomoharu" last="Kanie">Tomoharu Kanie</name><affiliation wicri:level="2"><nlm:affiliation>Baxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Baxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Lin, Chia Der" sort="Lin, Chia Der" uniqKey="Lin C" first="Chia-Der" last="Lin">Chia-Der Lin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Otorhinolaryngology, China Medical University Hospital, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Otorhinolaryngology, China Medical University Hospital, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Graduate Institute of Biomedical Sciences, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>School of Medicine, China Medical University, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Medicine, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author><author><name sortKey="Tsai, Ming Hsui" sort="Tsai, Ming Hsui" uniqKey="Tsai M" first="Ming-Hsui" last="Tsai">Ming-Hsui Tsai</name><affiliation wicri:level="1"><nlm:affiliation>Department of Otorhinolaryngology, China Medical University Hospital, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Otorhinolaryngology, China Medical University Hospital, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Graduate Institute of Biomedical Sciences, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>School of Medicine, China Medical University, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Medicine, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author><author><name sortKey="Phillips, Katie M" sort="Phillips, Katie M" uniqKey="Phillips K" first="Katie M" last="Phillips">Katie M. Phillips</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Kim, Raymond" sort="Kim, Raymond" uniqKey="Kim R" first="Raymond" last="Kim">Raymond Kim</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Overdevest, Jonathan B" sort="Overdevest, Jonathan B" uniqKey="Overdevest J" first="Jonathan B" last="Overdevest">Jonathan B. Overdevest</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Columbia University School of Medicine, New York City, NY.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Otolaryngology-Head and Neck Surgery, Columbia University School of Medicine, New York City</wicri:cityArea></affiliation></author><author><name sortKey="Tyler, Matthew A" sort="Tyler, Matthew A" uniqKey="Tyler M" first="Matthew A" last="Tyler">Matthew A. Tyler</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, University of Minnesota School of Medicine, Minneapolis, MN.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of Otolaryngology-Head and Neck Surgery, University of Minnesota School of Medicine, Minneapolis</wicri:cityArea></affiliation></author><author><name sortKey="Yan, Carol H" sort="Yan, Carol H" uniqKey="Yan C" first="Carol H" last="Yan">Carol H. Yan</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, University of California San Diego School of Medicine, San Diego, CA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Otolaryngology-Head and Neck Surgery, University of California San Diego School of Medicine, San Diego</wicri:cityArea></affiliation></author><author><name sortKey="Lin, Chih Feng" sort="Lin, Chih Feng" uniqKey="Lin C" first="Chih-Feng" last="Lin">Chih-Feng Lin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Otolaryngology, National Taiwan University Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Lin, Yi Tsen" sort="Lin, Yi Tsen" uniqKey="Lin Y" first="Yi-Tsen" last="Lin">Yi-Tsen Lin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Otolaryngology, National Taiwan University Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Bau, Da Tian" sort="Bau, Da Tian" uniqKey="Bau D" first="Da-Tian" last="Bau">Da-Tian Bau</name><affiliation wicri:level="1"><nlm:affiliation>Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Graduate Institute of Biomedical Sciences, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Terry Fox Cancer Research Laboratory, Translational Medicine Center, China Medical University Hospital, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Terry Fox Cancer Research Laboratory, Translational Medicine Center, China Medical University Hospital, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author><author><name sortKey="Tsay, Gregory J" sort="Tsay, Gregory J" uniqKey="Tsay G" first="Gregory J" last="Tsay">Gregory J. Tsay</name><affiliation wicri:level="1"><nlm:affiliation>School of Medicine, China Medical University, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Medicine, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Division of Immunology and Rheumatology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Division of Immunology and Rheumatology, Department of Internal Medicine, China Medical University Hospital, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author><author><name sortKey="Patel, Zara M" sort="Patel, Zara M" uniqKey="Patel Z" first="Zara M" last="Patel">Zara M. Patel</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Tsou, Yung An" sort="Tsou, Yung An" uniqKey="Tsou Y" first="Yung-An" last="Tsou">Yung-An Tsou</name><affiliation wicri:level="1"><nlm:affiliation>Department of Otorhinolaryngology, China Medical University Hospital, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Otorhinolaryngology, China Medical University Hospital, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>School of Medicine, China Medical University, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Medicine, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author><author><name sortKey="Tai, Chih Jaan" sort="Tai, Chih Jaan" uniqKey="Tai C" first="Chih-Jaan" last="Tai">Chih-Jaan Tai</name><affiliation wicri:level="1"><nlm:affiliation>Department of Otorhinolaryngology, China Medical University Hospital, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Otorhinolaryngology, China Medical University Hospital, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>School of Medicine, China Medical University, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Medicine, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author><author><name sortKey="Yeh, Te Huei" sort="Yeh, Te Huei" uniqKey="Yeh T" first="Te-Huei" last="Yeh">Te-Huei Yeh</name><affiliation wicri:level="1"><nlm:affiliation>Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Otolaryngology, National Taiwan University Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Hwang, Peter H" sort="Hwang, Peter H" uniqKey="Hwang P" first="Peter H" last="Hwang">Peter H. Hwang</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Nolan, Garry P" sort="Nolan, Garry P" uniqKey="Nolan G" first="Garry P" last="Nolan">Garry P. Nolan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, California 94305</wicri:regionArea><wicri:noRegion>California 94305</wicri:noRegion></affiliation><affiliation><nlm:affiliation>These authors jointly supervised this work: Garry P. Nolan, Jayakar V. Nayak, Peter K. Jackson.</nlm:affiliation><wicri:noCountry code="subField">Peter K</wicri:noCountry></affiliation></author><author><name sortKey="Nayak, Jayakar V" sort="Nayak, Jayakar V" uniqKey="Nayak J" first="Jayakar V" last="Nayak">Jayakar V. Nayak</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation><nlm:affiliation>These authors jointly supervised this work: Garry P. Nolan, Jayakar V. Nayak, Peter K. Jackson.</nlm:affiliation><wicri:noCountry code="subField">Peter K</wicri:noCountry></affiliation></author><author><name sortKey="Jackson, Peter K" sort="Jackson, Peter K" uniqKey="Jackson P" first="Peter K" last="Jackson">Peter K. Jackson</name><affiliation wicri:level="2"><nlm:affiliation>Baxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Baxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation><nlm:affiliation>These authors jointly supervised this work: Garry P. Nolan, Jayakar V. Nayak, Peter K. Jackson.</nlm:affiliation><wicri:noCountry code="subField">Peter K</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32511516</idno><idno type="pmid">32511516</idno><idno type="doi">10.1101/2020.05.08.20092866</idno><idno type="pmc">PMC7273284</idno><idno type="wicri:Area/Main/Corpus">000629</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000629</idno><idno type="wicri:Area/Main/Curation">000629</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000629</idno><idno type="wicri:Area/Main/Exploration">000629</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Robust ACE2 protein expression localizes to the motile cilia of the respiratory tract epithelia and is not increased by ACE inhibitors or angiotensin receptor blockers.</title><author><name sortKey="Lee, Ivan T" sort="Lee, Ivan T" uniqKey="Lee I" first="Ivan T" last="Lee">Ivan T. Lee</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, California 94305</wicri:regionArea><wicri:noRegion>California 94305</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation><nlm:affiliation>These authors contributed equally: Ivan T. Lee, Tsuguhisa Nakayama, Chien-Ting Wu, Yury Goltsev.</nlm:affiliation><wicri:noCountry code="subField">Yury Goltsev</wicri:noCountry></affiliation></author><author><name sortKey="Nakayama, Tsuguhisa" sort="Nakayama, Tsuguhisa" uniqKey="Nakayama T" first="Tsuguhisa" last="Nakayama">Tsuguhisa Nakayama</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation><nlm:affiliation>These authors contributed equally: Ivan T. Lee, Tsuguhisa Nakayama, Chien-Ting Wu, Yury Goltsev.</nlm:affiliation><wicri:noCountry code="subField">Yury Goltsev</wicri:noCountry></affiliation></author><author><name sortKey="Wu, Chien Ting" sort="Wu, Chien Ting" uniqKey="Wu C" first="Chien-Ting" last="Wu">Chien-Ting Wu</name><affiliation wicri:level="2"><nlm:affiliation>Baxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Baxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation><nlm:affiliation>These authors contributed equally: Ivan T. Lee, Tsuguhisa Nakayama, Chien-Ting Wu, Yury Goltsev.</nlm:affiliation><wicri:noCountry code="subField">Yury Goltsev</wicri:noCountry></affiliation></author><author><name sortKey="Goltsev, Yury" sort="Goltsev, Yury" uniqKey="Goltsev Y" first="Yury" last="Goltsev">Yury Goltsev</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, California 94305</wicri:regionArea><wicri:noRegion>California 94305</wicri:noRegion></affiliation><affiliation><nlm:affiliation>These authors contributed equally: Ivan T. Lee, Tsuguhisa Nakayama, Chien-Ting Wu, Yury Goltsev.</nlm:affiliation><wicri:noCountry code="subField">Yury Goltsev</wicri:noCountry></affiliation></author><author><name sortKey="Jiang, Sizun" sort="Jiang, Sizun" uniqKey="Jiang S" first="Sizun" last="Jiang">Sizun Jiang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, California 94305</wicri:regionArea><wicri:noRegion>California 94305</wicri:noRegion></affiliation></author><author><name sortKey="Gall, Phillip A" sort="Gall, Phillip A" uniqKey="Gall P" first="Phillip A" last="Gall">Phillip A. Gall</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Liao, Chun Kang" sort="Liao, Chun Kang" uniqKey="Liao C" first="Chun-Kang" last="Liao">Chun-Kang Liao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Otolaryngology, National Taiwan University Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Shih, Liang Chun" sort="Shih, Liang Chun" uniqKey="Shih L" first="Liang-Chun" last="Shih">Liang-Chun Shih</name><affiliation wicri:level="1"><nlm:affiliation>Department of Otorhinolaryngology, China Medical University Hospital, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Otorhinolaryngology, China Medical University Hospital, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Graduate Institute of Biomedical Sciences, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Terry Fox Cancer Research Laboratory, Translational Medicine Center, China Medical University Hospital, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Terry Fox Cancer Research Laboratory, Translational Medicine Center, China Medical University Hospital, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author><author><name sortKey="Schurch, Christian M" sort="Schurch, Christian M" uniqKey="Schurch C" first="Christian M" last="Schürch">Christian M. Schürch</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, California 94305</wicri:regionArea><wicri:noRegion>California 94305</wicri:noRegion></affiliation></author><author><name sortKey="Mcilwain, David R" sort="Mcilwain, David R" uniqKey="Mcilwain D" first="David R" last="Mcilwain">David R. Mcilwain</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, California 94305</wicri:regionArea><wicri:noRegion>California 94305</wicri:noRegion></affiliation></author><author><name sortKey="Chu, Pauline" sort="Chu, Pauline" uniqKey="Chu P" first="Pauline" last="Chu">Pauline Chu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, California 94305</wicri:regionArea><wicri:noRegion>California 94305</wicri:noRegion></affiliation></author><author><name sortKey="Borchard, Nicole A" sort="Borchard, Nicole A" uniqKey="Borchard N" first="Nicole A" last="Borchard">Nicole A. Borchard</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Zarabanda, David" sort="Zarabanda, David" uniqKey="Zarabanda D" first="David" last="Zarabanda">David Zarabanda</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Dholakia, Sachi S" sort="Dholakia, Sachi S" uniqKey="Dholakia S" first="Sachi S" last="Dholakia">Sachi S. Dholakia</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Yang, Angela" sort="Yang, Angela" uniqKey="Yang A" first="Angela" last="Yang">Angela Yang</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Kim, Dayoung" sort="Kim, Dayoung" uniqKey="Kim D" first="Dayoung" last="Kim">Dayoung Kim</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Kanie, Tomoharu" sort="Kanie, Tomoharu" uniqKey="Kanie T" first="Tomoharu" last="Kanie">Tomoharu Kanie</name><affiliation wicri:level="2"><nlm:affiliation>Baxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Baxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Lin, Chia Der" sort="Lin, Chia Der" uniqKey="Lin C" first="Chia-Der" last="Lin">Chia-Der Lin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Otorhinolaryngology, China Medical University Hospital, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Otorhinolaryngology, China Medical University Hospital, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Graduate Institute of Biomedical Sciences, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>School of Medicine, China Medical University, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Medicine, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author><author><name sortKey="Tsai, Ming Hsui" sort="Tsai, Ming Hsui" uniqKey="Tsai M" first="Ming-Hsui" last="Tsai">Ming-Hsui Tsai</name><affiliation wicri:level="1"><nlm:affiliation>Department of Otorhinolaryngology, China Medical University Hospital, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Otorhinolaryngology, China Medical University Hospital, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Graduate Institute of Biomedical Sciences, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>School of Medicine, China Medical University, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Medicine, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author><author><name sortKey="Phillips, Katie M" sort="Phillips, Katie M" uniqKey="Phillips K" first="Katie M" last="Phillips">Katie M. Phillips</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Kim, Raymond" sort="Kim, Raymond" uniqKey="Kim R" first="Raymond" last="Kim">Raymond Kim</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Overdevest, Jonathan B" sort="Overdevest, Jonathan B" uniqKey="Overdevest J" first="Jonathan B" last="Overdevest">Jonathan B. Overdevest</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Columbia University School of Medicine, New York City, NY.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Otolaryngology-Head and Neck Surgery, Columbia University School of Medicine, New York City</wicri:cityArea></affiliation></author><author><name sortKey="Tyler, Matthew A" sort="Tyler, Matthew A" uniqKey="Tyler M" first="Matthew A" last="Tyler">Matthew A. Tyler</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, University of Minnesota School of Medicine, Minneapolis, MN.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of Otolaryngology-Head and Neck Surgery, University of Minnesota School of Medicine, Minneapolis</wicri:cityArea></affiliation></author><author><name sortKey="Yan, Carol H" sort="Yan, Carol H" uniqKey="Yan C" first="Carol H" last="Yan">Carol H. Yan</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, University of California San Diego School of Medicine, San Diego, CA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Otolaryngology-Head and Neck Surgery, University of California San Diego School of Medicine, San Diego</wicri:cityArea></affiliation></author><author><name sortKey="Lin, Chih Feng" sort="Lin, Chih Feng" uniqKey="Lin C" first="Chih-Feng" last="Lin">Chih-Feng Lin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Otolaryngology, National Taiwan University Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Lin, Yi Tsen" sort="Lin, Yi Tsen" uniqKey="Lin Y" first="Yi-Tsen" last="Lin">Yi-Tsen Lin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Otolaryngology, National Taiwan University Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Bau, Da Tian" sort="Bau, Da Tian" uniqKey="Bau D" first="Da-Tian" last="Bau">Da-Tian Bau</name><affiliation wicri:level="1"><nlm:affiliation>Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Graduate Institute of Biomedical Sciences, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Terry Fox Cancer Research Laboratory, Translational Medicine Center, China Medical University Hospital, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Terry Fox Cancer Research Laboratory, Translational Medicine Center, China Medical University Hospital, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author><author><name sortKey="Tsay, Gregory J" sort="Tsay, Gregory J" uniqKey="Tsay G" first="Gregory J" last="Tsay">Gregory J. Tsay</name><affiliation wicri:level="1"><nlm:affiliation>School of Medicine, China Medical University, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Medicine, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Division of Immunology and Rheumatology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Division of Immunology and Rheumatology, Department of Internal Medicine, China Medical University Hospital, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author><author><name sortKey="Patel, Zara M" sort="Patel, Zara M" uniqKey="Patel Z" first="Zara M" last="Patel">Zara M. Patel</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Tsou, Yung An" sort="Tsou, Yung An" uniqKey="Tsou Y" first="Yung-An" last="Tsou">Yung-An Tsou</name><affiliation wicri:level="1"><nlm:affiliation>Department of Otorhinolaryngology, China Medical University Hospital, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Otorhinolaryngology, China Medical University Hospital, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>School of Medicine, China Medical University, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Medicine, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author><author><name sortKey="Tai, Chih Jaan" sort="Tai, Chih Jaan" uniqKey="Tai C" first="Chih-Jaan" last="Tai">Chih-Jaan Tai</name><affiliation wicri:level="1"><nlm:affiliation>Department of Otorhinolaryngology, China Medical University Hospital, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Otorhinolaryngology, China Medical University Hospital, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>School of Medicine, China Medical University, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Medicine, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author><author><name sortKey="Yeh, Te Huei" sort="Yeh, Te Huei" uniqKey="Yeh T" first="Te-Huei" last="Yeh">Te-Huei Yeh</name><affiliation wicri:level="1"><nlm:affiliation>Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Otolaryngology, National Taiwan University Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Hwang, Peter H" sort="Hwang, Peter H" uniqKey="Hwang P" first="Peter H" last="Hwang">Peter H. Hwang</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Nolan, Garry P" sort="Nolan, Garry P" uniqKey="Nolan G" first="Garry P" last="Nolan">Garry P. Nolan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, California 94305</wicri:regionArea><wicri:noRegion>California 94305</wicri:noRegion></affiliation><affiliation><nlm:affiliation>These authors jointly supervised this work: Garry P. Nolan, Jayakar V. Nayak, Peter K. Jackson.</nlm:affiliation><wicri:noCountry code="subField">Peter K</wicri:noCountry></affiliation></author><author><name sortKey="Nayak, Jayakar V" sort="Nayak, Jayakar V" uniqKey="Nayak J" first="Jayakar V" last="Nayak">Jayakar V. Nayak</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation><nlm:affiliation>These authors jointly supervised this work: Garry P. Nolan, Jayakar V. Nayak, Peter K. Jackson.</nlm:affiliation><wicri:noCountry code="subField">Peter K</wicri:noCountry></affiliation></author><author><name sortKey="Jackson, Peter K" sort="Jackson, Peter K" uniqKey="Jackson P" first="Peter K" last="Jackson">Peter K. Jackson</name><affiliation wicri:level="2"><nlm:affiliation>Baxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Baxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation><nlm:affiliation>These authors jointly supervised this work: Garry P. Nolan, Jayakar V. Nayak, Peter K. Jackson.</nlm:affiliation><wicri:noCountry code="subField">Peter K</wicri:noCountry></affiliation></author></analytic><series><title level="j">medRxiv : the preprint server for health sciences</title><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We investigated the expression and subcellular localization of the SARS-CoV-2 receptor, angiotensin-converting enzyme 2 (ACE2), within the upper (nasal) and lower (pulmonary) respiratory tracts of healthy human donors. We detected ACE2 protein expression within the cilia organelle of ciliated airway epithelial cells, which likely represents the initial or early subcellular site of SARS-CoV-2 viral entry during respiratory transmission. We further determined whether ACE2 expression in the cilia of upper respiratory cells was influenced by patient demographics, clinical characteristics, co-morbidities, or medication use, and found no evidence that the use of angiotensin-converting enzyme inhibitors (ACEI) or angiotensin II receptor blockers (ARBs) increases ACE2 protein expression.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">32511516</PMID><DateRevised><Year>2020</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Electronic"><Journal><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>May</Month><Day>12</Day></PubDate></JournalIssue><Title>medRxiv : the preprint server for health sciences</Title><ISOAbbreviation>medRxiv</ISOAbbreviation></Journal><ArticleTitle>Robust ACE2 protein expression localizes to the motile cilia of the respiratory tract epithelia and is not increased by ACE inhibitors or angiotensin receptor blockers.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">2020.05.08.20092866</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1101/2020.05.08.20092866</ELocationID><Abstract><AbstractText>We investigated the expression and subcellular localization of the SARS-CoV-2 receptor, angiotensin-converting enzyme 2 (ACE2), within the upper (nasal) and lower (pulmonary) respiratory tracts of healthy human donors. We detected ACE2 protein expression within the cilia organelle of ciliated airway epithelial cells, which likely represents the initial or early subcellular site of SARS-CoV-2 viral entry during respiratory transmission. We further determined whether ACE2 expression in the cilia of upper respiratory cells was influenced by patient demographics, clinical characteristics, co-morbidities, or medication use, and found no evidence that the use of angiotensin-converting enzyme inhibitors (ACEI) or angiotensin II receptor blockers (ARBs) increases ACE2 protein expression.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Ivan T</ForeName><Initials>IT</Initials><AffiliationInfo><Affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>These authors contributed equally: Ivan T. Lee, Tsuguhisa Nakayama, Chien-Ting Wu, Yury Goltsev.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nakayama</LastName><ForeName>Tsuguhisa</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>These authors contributed equally: Ivan T. Lee, Tsuguhisa Nakayama, Chien-Ting Wu, Yury Goltsev.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Chien-Ting</ForeName><Initials>CT</Initials><AffiliationInfo><Affiliation>Baxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, California, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>These authors contributed equally: Ivan T. Lee, Tsuguhisa Nakayama, Chien-Ting Wu, Yury Goltsev.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Goltsev</LastName><ForeName>Yury</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>These authors contributed equally: Ivan T. Lee, Tsuguhisa Nakayama, Chien-Ting Wu, Yury Goltsev.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jiang</LastName><ForeName>Sizun</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gall</LastName><ForeName>Phillip A</ForeName><Initials>PA</Initials><AffiliationInfo><Affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liao</LastName><ForeName>Chun-Kang</ForeName><Initials>CK</Initials><AffiliationInfo><Affiliation>Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shih</LastName><ForeName>Liang-Chun</ForeName><Initials>LC</Initials><AffiliationInfo><Affiliation>Department of Otorhinolaryngology, China Medical University Hospital, Taichung, Taiwan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Terry Fox Cancer Research Laboratory, Translational Medicine Center, China Medical University Hospital, Taichung, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schürch</LastName><ForeName>Christian M</ForeName><Initials>CM</Initials><AffiliationInfo><Affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McIlwain</LastName><ForeName>David R</ForeName><Initials>DR</Initials><AffiliationInfo><Affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chu</LastName><ForeName>Pauline</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Borchard</LastName><ForeName>Nicole A</ForeName><Initials>NA</Initials><AffiliationInfo><Affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zarabanda</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dholakia</LastName><ForeName>Sachi S</ForeName><Initials>SS</Initials><AffiliationInfo><Affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Angela</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Dayoung</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kanie</LastName><ForeName>Tomoharu</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Baxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, California, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lin</LastName><ForeName>Chia-Der</ForeName><Initials>CD</Initials><AffiliationInfo><Affiliation>Department of Otorhinolaryngology, China Medical University Hospital, Taichung, Taiwan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Medicine, China Medical University, Taichung, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tsai</LastName><ForeName>Ming-Hsui</ForeName><Initials>MH</Initials><AffiliationInfo><Affiliation>Department of Otorhinolaryngology, China Medical University Hospital, Taichung, Taiwan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Medicine, China Medical University, Taichung, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Phillips</LastName><ForeName>Katie M</ForeName><Initials>KM</Initials><AffiliationInfo><Affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Raymond</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Overdevest</LastName><ForeName>Jonathan B</ForeName><Initials>JB</Initials><AffiliationInfo><Affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Otolaryngology-Head and Neck Surgery, Columbia University School of Medicine, New York City, NY.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tyler</LastName><ForeName>Matthew A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Otolaryngology-Head and Neck Surgery, University of Minnesota School of Medicine, Minneapolis, MN.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yan</LastName><ForeName>Carol H</ForeName><Initials>CH</Initials><AffiliationInfo><Affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Otolaryngology-Head and Neck Surgery, University of California San Diego School of Medicine, San Diego, CA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lin</LastName><ForeName>Chih-Feng</ForeName><Initials>CF</Initials><AffiliationInfo><Affiliation>Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lin</LastName><ForeName>Yi-Tsen</ForeName><Initials>YT</Initials><AffiliationInfo><Affiliation>Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bau</LastName><ForeName>Da-Tian</ForeName><Initials>DT</Initials><AffiliationInfo><Affiliation>Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Terry Fox Cancer Research Laboratory, Translational Medicine Center, China Medical University Hospital, Taichung, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tsay</LastName><ForeName>Gregory J</ForeName><Initials>GJ</Initials><AffiliationInfo><Affiliation>School of Medicine, China Medical University, Taichung, Taiwan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Immunology and Rheumatology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Patel</LastName><ForeName>Zara M</ForeName><Initials>ZM</Initials><AffiliationInfo><Affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tsou</LastName><ForeName>Yung-An</ForeName><Initials>YA</Initials><AffiliationInfo><Affiliation>Department of Otorhinolaryngology, China Medical University Hospital, Taichung, Taiwan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Medicine, China Medical University, Taichung, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tai</LastName><ForeName>Chih-Jaan</ForeName><Initials>CJ</Initials><AffiliationInfo><Affiliation>Department of Otorhinolaryngology, China Medical University Hospital, Taichung, Taiwan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Medicine, China Medical University, Taichung, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yeh</LastName><ForeName>Te-Huei</ForeName><Initials>TH</Initials><AffiliationInfo><Affiliation>Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hwang</LastName><ForeName>Peter H</ForeName><Initials>PH</Initials><AffiliationInfo><Affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nolan</LastName><ForeName>Garry P</ForeName><Initials>GP</Initials><AffiliationInfo><Affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>These authors jointly supervised this work: Garry P. Nolan, Jayakar V. Nayak, Peter K. Jackson.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nayak</LastName><ForeName>Jayakar V</ForeName><Initials>JV</Initials><AffiliationInfo><Affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>These authors jointly supervised this work: Garry P. Nolan, Jayakar V. Nayak, Peter K. Jackson.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jackson</LastName><ForeName>Peter K</ForeName><Initials>PK</Initials><AffiliationInfo><Affiliation>Baxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, California, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>These authors jointly supervised this work: Garry P. Nolan, Jayakar V. Nayak, Peter K. Jackson.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>P30 DK116074</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AI149672</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D000076942">Preprint</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>05</Month><Day>12</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>medRxiv</MedlineTA><NlmUniqueID>101767986</NlmUniqueID></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="UpdateIn"><RefSource>Nat Commun. 2020 Oct 28;11(1):5453</RefSource><PMID Version="1">33116139</PMID></CommentsCorrections></CommentsCorrectionsList></MedlineCitation><PubmedData><History><PubMedPubDate 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Tsay</name><name sortKey="Tsay, Gregory J" sort="Tsay, Gregory J" uniqKey="Tsay G" first="Gregory J" last="Tsay">Gregory J. Tsay</name><name sortKey="Tsou, Yung An" sort="Tsou, Yung An" uniqKey="Tsou Y" first="Yung-An" last="Tsou">Yung-An Tsou</name><name sortKey="Tsou, Yung An" sort="Tsou, Yung An" uniqKey="Tsou Y" first="Yung-An" last="Tsou">Yung-An Tsou</name><name sortKey="Yeh, Te Huei" sort="Yeh, Te Huei" uniqKey="Yeh T" first="Te-Huei" last="Yeh">Te-Huei Yeh</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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